TURN ON YOUR LONGEVITY GENES
Secret Reason Why Centenarians Live So Long
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SUMMARY OF AUTHOR’S THOUGHTS
Calorie restriction can activate certain longevity pathways, but it doesn’t always lead to optimal health outcomes. To increase the activation of foxo proteins, which play a role in mediating the benefits of calorie restriction, one can engage in hormetic stressors such as calorie restriction, fasting, exercise, heat shock, cold exposure, and hypoxia. Certain natural compounds, such as xanthin from seafood and alpha lipoic acid from vegetables, can also increase foxo3 activation. Another longevity gene or pathway associated with centenarians is autophagy, which can also be activated by similar hormetic stressors, such as exercise, fasting, and phytonutrients found in coffee, green tea, and dietary polyphenols.
IN THEIR OWN WORDS…
There are some people who live over 100 years old even if they have like a you know mediocre or even an unhealthy lifestyle. Like, they smoke, they eat chocolate, and they don’t take care of their health that much. Of course, there are some genetic factors that play here, and there are certain genes that are associated more with longevity. So in this video, I’m going to talk about these longevity genes that make you live longer and how can you turn them on.
Do it, I think a good place to start is with the blue zones. So, icaria and Sardinia are one of the blue zones in the world where people are exceptionally living longer. There are certain like genetic features that have been found to be associated with the centenarian hot spots. And when it comes to the Korea and Sardinia region then the two biggest like you know genetic characteristics are that they have better apoe genes as well as the foxho 3A jeans.
Apoe gene refers to your body’s ability to metabolize saturated fat and cholesterol as well as insulin resistance. People who have the apoe3 and 4 allele have a much higher risk of getting Alzheimer’s or heart disease if they consume saturated fat in their diet compared to individuals who have the apoe 2 or 2 and 3 allele. I think that this is actually a very big like a determining factor whether or not you should be eating like a high saturated fat or not. And the individuals who do have apoe three or four allele then for them, it’s much safer to not be eating like a lot of saturated fat and to eat mostly like you know more pollen saturated fats, monounsaturated fats, and also be on like a more you know less fatty diet.
But the much more interesting gene that we’re going to talk about in this video is going to be foxo3a, and that translates into 4K the Box o3a Gene which refers to your bodies or is a gene that regulates your energy sensing pathways like insulin, igf-1, and ampk. So these are pretty much nutrient sensing pathways and there is a lot of associations between the foxo3a variation and human longevity pretty much in multiple studies. Even in the Italians again the Foxworth 3A there is a big association with foxo3a and increased longevity even like extreme centenarianism. Even if you adjust for smoking then foxo3a is still associated with longevity so uh yeah like even people who smoke and have like a general unhealthy lifestyle then if you do have you know better voxel 3A genes then they still have a better longevity even if they do smoke. So that probably explains a lot of these longevity hotspots who do live longer despite being learned like not that healthy apparently not healthy like diet and they kind of smoke and drink.
So this I think this is the biggest reason why they do kind of live longer from a genetic standpoint that they have a lot of this voxel 3A genes in there like local environment in terms of the population. So like I said foxo proteins and Foxy 3A specifically are regulated in the nutrient sensing pathways like insulin Nitric one ampk so either like a growing or you’re in a category state that controls things like ethology and those things antioxidant defense systems and nerf2 those are yeah linked to also this foxo 3 activation through the ampk pathway. The fox so transcription factor Foxo3 is a part of igf-1 and it is essential apparently for getting the benefits from calorie restriction as well for longevity in terms of you know you know calorie restriction is great in terms of having the activation of these many longevity pathways but you know it doesn’t necessarily always work in terms of leading to frailty and the muscle.
Calorie restriction is great in terms of having the activation of these many longevity pathways, but it doesn’t necessarily always work in terms of leading to frailty and muscle loss that can be harmful for overall longevity. However, you do need to make sure that you know the foxo proteins apparently mediate a lot of the calorie restriction benefits that you get and of course, foreign proteins but yeah you know there’s different ways to restrict calories.
You can be on a very high sugar low protein diet which arguably wouldn’t you know enable the activation of these pathways at least like in in uh in the best optimal way. AMPK which is impacted protein kinase also gets activated a lot of these by a lot of these hermetic positive energy stressors and yeah it does have a direct impact on the foxo proteins as well including sirtuins, autology and the mtor suppression. So how do you increase fox or protein activation? I have written an article about it and there are pretty much you know the standard hormetic stressors that we’ve already talked about. Calorie restriction, fasting, even just acute exercise, heat shock, cold exposure and hypoxia even so that you can train with some breathing exercises or the you know exercise already induces a mild hypoxia.
You don’t want to be under chronic hypoxia that’s gonna actually promote cancer but you know the acute hypoxia that you get from some sort of brief breath work or exercise is that’s what you kind of want. Some natural compounds that can also increase Foxho3 are as the xanthin that you get from seafood like fish, alpha lipoic acid that you can get from foods like broccoli, carrot, spinach, meat, organ meat etc and green tea polyphenols like EGCG activate foxo3.
The second longevity gene or let’s say you know pathway that is also associated a lot with the Centenarians is a tobajim and there are like the centenarians have higher expression and higher like biomarkers of Pectin 1 which is an autography protein and like a reflection of autologism. Centenarians or people who live over 100 also have enhanced autophagy lysosomal function so they have just like a higher baseline of autophagy activated all the time. And with autology, you know you can also activate it with the similar things that the froxoproteins like exercise, some form of intimate fasting and geometry reading color restriction and these hermetic stressors hermetic foods like coffee, green tea, dietary polyphenols and phytonutrients.
In conclusion, you know there are certain genetic factors that the centenarians apparently have more than some other individuals. You know one of the biggest ones is the apoe thing that they have a more favorable ipoe gene allele that kind of protects themselves against Alzheimer’s and heart disease.
There are also these elevation of voxel-3 and better voxo3 activation probably like you know that are genetically more easily to activate these factors or they have like a higher baseline of photography all the time. And yeah there are like these genes that the centenarians apparently have and that protects them against some unhealthy lifestyle but also pretty much enhances their already existing lifestyle of whatever they’re doing. So they’re going to get more benefits from exercise, they’re going to get more benefits on calorie restriction, etc.
But it doesn’t mean that if you don’t have these higher baseline of these certain genetic like factors then you can still obviously live very long and be healthy at the same time because you know epigenetics is more powerful than genetics. The Epi means above genetics so genetics is just like the predisposing factors but whether or not some genes get turned on or not depends on you know the epigenetics of your lifestyle and what you do. And the vast majority of longevity is concluded that it is dependent of like your epigenetics and you can always take control of the direction of your health.
SOME ADDITIONAL RESOURCES
Why People in “Blue Zones” Live Longer Than the Rest of the World
Chronic diseases are becoming more and more common in old age.
While genetics somewhat determine your lifespan and susceptibility to these diseases, your lifestyle probably has a greater impact.
A few places in the world are called “Blue Zones.” The term refers to geographic areas in which people have low rates of chronic disease and live longer than anywhere else.
This article describes the common lifestyle features of people in Blue Zones, including why they live longer.
Secret to Longer Life is Low-Tech
For 30 years, my life’s work has been identifying and then studying extraordinary populations around the world and unlocking their secrets to longevity and happiness.
Several longevity hotspots surfaced through my expeditions — the Barbagia region of Sardinia, Italy; Ikaria, Greece; Okinawa, Japan; the Nicoya Peninsula in Costa Rica; and Loma Linda, California. People in these blue zones regions not just live longer, but they live better. Besides having a large number of centenarians, people in these areas remain active into their 80s and 90s and do not suffer from the chronic diseases common in most parts of the industrialized world. Armed with a team of demographers and scientists and a grant from the National Institute on Aging, we set out to reverse-engineer longevity, or establish why these populations live the healthiest and longest lives in the world.
The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel or website.